PRKDC (phospho T2609) polyclonal antibody
产品名称： PRKDC (phospho T2609) polyclonal antibody
英文名称： PRKDC (phospho T2609) polyclonal antibody
产品编号： PAB1636
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of PRKDC.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T2609 of human PRKDC.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.
Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, Meek K.Mol Cell Biol. 2003 Aug;23(16):5836-48.
- 2.
- Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex.
Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y.J Biol Chem. 2003 Aug 8;278(32):29940-7. Epub 2003 May 19.
- 3.
- Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response.
Lucero H, Gae D, Taccioli GE.J Biol Chem. 2003 Jun 13;278(24):22136-43. Epub 2003 Apr 2.
- Entrez GeneID:
- 5591
- Protein Accession#:
- P78527
- Gene Name:
- PRKDC
- Gene Alias:
- DNA-PKcs,DNAPK,DNPK1,HYRC,HYRC1,XRCC7,p350
- Gene Description:
- protein kinase, DNA-activated, catalytic polypeptide
- Omim ID:
- 600899
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM
- Other Designations:
- hyper-radiosensitivity of murine scid mutation, complementing 1
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Ataxia telangiectasia
- Bone Neoplasms
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Papillary
- Carcinoma, Renal Cell
- Carcinoma, Transitional Cell
- Central Nervous System Neoplasms
- DNA Damage
- Genetic Predisposition to Disease
- Glioma
- Head and Neck Neoplasms
- Hematologic Diseases
- Hodgkin Disease
- Kidney Neoplasms
- Lung Neoplasms
- Lymphoma, Non-Hodgkin